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  • Title: Myopia and Exposure to Organophosphate and Pyrethroid Pesticides in the General United States Population.
    Author: Migneron-Foisy V, Bouchard MF, Freeman EE, Saint-Amour D.
    Journal: Invest Ophthalmol Vis Sci; 2017 Sep 01; 58(11):4915-4924. PubMed ID: 28973337.
    Abstract:
    PURPOSE: Previous research suggests that exposure to pesticides might be associated with human myopia, although data were obtained only from highly exposed individuals. The present study aimed to assess whether exposure to organophosphates and pyrethroids in the United States general population was associated with the prevalence of myopia. METHODS: Data were obtained from the National Health and Nutrition Examination Survey (NHANES, years 1999-2008). One-spot urine samples were used to estimate the concentration of several pesticide metabolites. Exposure data and equivalent spherical refraction errors were available for 5147 and 2911 individuals for organophosphates and pyrethroids, respectively. Multiple logistic regression models were used to assess the relation between log10-transformed urinary levels of pesticide metabolites and the risk of moderate (≤-1 and >-5 diopters [D]) and high myopia (≤-5 D) in adolescents (12- to 19-years old) and young adults (20- to 40-years old). Models were adjusted for sex, age, ethnicity, diabetes, creatinine, cadmium and lead concentrations, and income in both age groups, but also for education level and cigarette and alcohol consumption in the adult group. RESULTS: No association between organophosphates or pyrethroid metabolites and myopia was observed. However, after adjusting for education level and cigarette and alcohol consumption, a statistically significant decreased risk of high myopia in those with a 10-fold increase of dialkyl phosphate metabolites was found in adults but only in men (P < 0.05). CONCLUSIONS: Our results suggest that exposure to organophosphates or pyrethroids do not increase the risk of myopia in the United States general population.
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