These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: An excitatory amino acid projection from ventromedial hypothalamus to periaqueductal gray in the rat: autoradiographic and electrophysiological evidence.
    Author: Beart PM, Nicolopoulos LS, West DC, Headley PM.
    Journal: Neurosci Lett; 1988 Feb 29; 85(2):205-11. PubMed ID: 2897646.
    Abstract:
    The projection from ventromedial hypothalamus (VMH) to periaqueductal gray (PAG) has been implicated in various physiological processes in the rat, but the neurotransmitter mediating the excitatory response in PAG has not been identified. This pathway has been studied using a combination of anatomical and electrophysiological techniques. The retrograde labelling by D-[3H]aspartate in VMH, following injections into PAG, was particularly dense, suggesting that an excitatory amino acid may be the transmitter. This postulate is strengthened since VMH-evoked synaptic responses in PAG were reduced by microelectrophoretically administered antagonists of excitatory amino acids. Receptors of the N-methyl-D-aspartate and non-N-methyl-D-aspartate types appear to have a functional role in this projection.
    [Abstract] [Full Text] [Related] [New Search]