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  • Title: Multiple Evanescent White Dot Syndrome: A Multimodal Imaging Study of Foveal Granularity.
    Author: Mantovani A, Invernizzi A, Staurenghi G, Herbort CP.
    Journal: Ocul Immunol Inflamm; 2019; 27(1):141-147. PubMed ID: 28981397.
    Abstract:
    PURPOSE: To describe multiple evanescent white dot syndrome (MEWDS)-related foveal granularity features on different imaging modalities. METHODS: Clinical and multi-imaging files from five patients affected by MEWDS were reviewed. Each image set included: blue fundus autofluorescence (BAF), near-infrared fundus autofluorescence (NIR-FAF), spectral-domain optical coherence tomography (SD-OCT), fluorescein (FA), and indocyanine green (ICGA) angiography. Foveal granularity features were analyzed and described for each technique at baseline and follow-up. RESULTS: At baseline, 4/5 patients did not show white dots at funduscopic examination, but all subjects demonstrated hypo-fluorescent lesions on ICGA and areas of increased BAF. In all patients, foveal granularity was detectable on NIR-FAF as an irregular hypo-fluorescent area, persisting during follow-up visits. The corresponding SD-OCT scans revealed outer retinal layers' disruption resolving overtime. CONCLUSIONS: Foveal granularity can be the sole presenting sign of MEWDS. NIR-FAF and SD-OCT should be considered as non-invasive investigations in the detection of MEWDS-related foveal granularity.
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