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  • Title: Epithelial dysfunction and airway hyperreactivity in asthma.
    Author: Goldie RG, Fernandes LB, Rigby PJ, Paterson JW.
    Journal: Prog Clin Biol Res; 1988; 263():317-29. PubMed ID: 2898153.
    Abstract:
    It is clear that the central airway epithelium plays an important role in restricting access of inhaled solutes to sub-epithelial airway wall structures. Non-specific airway hyperreactivity to spasmogens in asthma may result partly as a consequence of the compromise of the epithelium as a barrier to solute diffusion. However, impaired epithelial production and release of smooth muscle relaxant factor(s) may also contribute to airway hyperresponsiveness. Virally precipitated asthma also involves inflammation-induced epithelial damage. Beta-adrenoceptor hypofunction induced by respiratory viruses may also contribute to bronchial obstruction.
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