These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of prednisolone and ketotifen on beta 2-adrenoceptors in asthmatic patients receiving beta 2-bronchodilators.
    Author: Brodde OE, Howe U, Egerszegi S, Konietzko N, Michel MC.
    Journal: Eur J Clin Pharmacol; 1988; 34(2):145-50. PubMed ID: 2898369.
    Abstract:
    In 13 patients with bronchial asthma, who were on beta 2-adrenergic bronchodilator therapy, the effects of prednisolone and ketotifen on lymphocyte beta 2-adrenoceptor density and -responsiveness were investigated. The mean lymphocyte beta 2-adrenoceptor density and -responsiveness was significantly lower than in healthy controls, presumably due to the long-term beta 2-adrenergic bronchodilator treatment. Both prednisolone 100 mg i.v. and ketotifen 1 mg b.d.p.o. for 6 days rapidly improved lymphocyte beta 2-adrenoceptor function. 16 h after prednisolone and about 6 days after the first dose of ketotifen lymphocyte beta 2-adrenoceptor density and -responsiveness had risen to values within the range in normal volunteers. The improvement of lymphocyte beta 2-adrenoceptor function was accompanied by a significant increase in peak expiratory flow rate before and after inhalation of salbutamol. It is concluded that prednisolone and ketotifen may act beneficially on the recovery of beta 2-adrenoceptor responsiveness to beta 2-adrenergic bronchodilators in tolerant asthmatic patients.
    [Abstract] [Full Text] [Related] [New Search]