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  • Title: Synthesis and beta-adrenergic blocking activity of oxipropanolamines of 3,4-dihydro-3-oxo-2H(1,4)benzothiazine.
    Author: Cecchetti V, Fravolini A, Fringuelli R, Schiaffella F, Mascellani G, Pagella PG, Rugarli PL.
    Journal: Farmaco Sci; 1987 Jan; 42(1):61-75. PubMed ID: 2898382.
    Abstract:
    The synthesis of a series of oxypropanolamines of 3,4-dihydro-3-oxo-2H(1,4)benzothiazine is reported. Some of these compounds proved more potent than propranolol and carteolol as beta-adrenergic blocking agents in in vitro tests. The 8-(3-tert-butylamino-2-hydroxy)propoxy-3,4-dihydro-3-oxo-2H(1,4) benzothiazine fumarate (XVI a), which gave better results, confirmed its remarkable activity in in vivo tests.
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