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  • Title: At least three human homeoboxes on chromosome 12 belong to the same transcription unit.
    Author: Simeone A, Pannese M, Acampora D, D'Esposito M, Boncinelli E.
    Journal: Nucleic Acids Res; 1988 Jun 24; 16(12):5379-90. PubMed ID: 2898768.
    Abstract:
    Mammalian homeoboxes show a clustered chromosomal organization. In the mouse, at least seven homeoboxes on chromosome 6 and at least six on chromosome 11 identify the murine Hox-1 and Hox-2 loci, respectively. A number of homeoboxes on chromosome 7 define the human HOX-1 locus and homeoboxes on chromosome 17 define the human HOX-2 locus. We studied the genomic organization of three homeobox sequences of the HOX-3 locus on chromosome 12 and analyzed transcripts from this region. Structural characterization and sequencing of several cDNA clones reveal that the three homeobox sequences present in this chromosomal region identify a single transcription unit. Primary transcripts are alternatively processed to give mature messengers with a common 5' noncoding exon encoding different proteins containing one of the three homeodomains.
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