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  • Title: Purification and characterization of mouse hematopoietic stem cells.
    Author: Spangrude GJ, Heimfeld S, Weissman IL.
    Journal: Science; 1988 Jul 01; 241(4861):58-62. PubMed ID: 2898810.
    Abstract:
    Mouse bone marrow hematopoietic stem cells were isolated with the use of a variety of phenotypic markers. These cells can proliferate and differentiate with approximately unit efficiency into myelomonocytic cells, B cells, or T cells. Thirty of these cells are sufficient to save 50 percent of lethally irradiated mice, and to reconstitute all blood cell types in the survivors.
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