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  • Title: [Alkyl- and alkoxy-substituted lamtidine analogs: synthesis and H2-antagonistic activity. 38. H2-antihistaminics].
    Author: Bonjean VJ, Schunack W.
    Journal: Arzneimittelforschung; 1988 Apr; 38(4):501-7. PubMed ID: 2900010.
    Abstract:
    In studies on the structure-activity relationships of histamine H2-receptor antagonists, lamtidine analogous derivatives of ortho-, meta- und para-substituted piperidinomethylphenoxypropylamines bearing an additional substituent on the aromatic ring were prepared and tested for their H2-antagonistic activity on the isolated guinea-pig atrium. An additional substituent decreases the H2-antagonistic activity of the 3-(3-piperidinomethyl-phenoxy)-propylamine derivatives, while 2-membered substituents neighboring the connecting chain increase the activity of the ortho- and para-piperidinomethyl-substituted phenoxypropylamine derivatives.
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