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  • Title: Bradykinin activates tyrosine hydroxylase in rat pheochromocytoma PC-12 cells.
    Author: Houchi H, Masserano JM, Weiner N.
    Journal: FEBS Lett; 1988 Aug 01; 235(1-2):137-40. PubMed ID: 2900157.
    Abstract:
    Tyrosine hydroxylase is activated in PC-12 cells by bradykinin in a concentration-dependent manner with maximal stimulation occurring at 1 microM. This stimulatory effect occurs within 15 s and is maximal at 5 min. This stimulation is due to an increase in the affinity of tyrosine hydroxylase for its pterin cofactor, and can be blocked by a specific bradykinin receptor antagonist. These data indicate that bradykinin can regulate the activity of tyrosine hydroxylase in PC-12 cells.
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