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  • Title: [Pathways of the synthesis of glutamic acid by cephalosporin C-producing Acremonium chrysogenum].
    Author: Krakhmaleva IN, Telesnina GN, Petiushenko RM.
    Journal: Antibiot Khimioter; 1988 May; 33(5):327-30. PubMed ID: 2901250.
    Abstract:
    There were observed two pathways of glutamic acid formation in two strains of Acremonium chrysogenum differing in the production levels of cephalosporin C. The pathway involving glutamate dehydrogenase is known. The other pathway involved amination catalyzed by glutamine synthetase. Activity of both the enzymes during intensive synthesis of the antibiotic was higher in the highly productive strain. Under conditions of limited nitrogen content in the medium production of glutamate during the antibiotic biosynthesis depended on glutamine synthetase. When there was an excess of nitrogen in the medium the main role in production of glutamic acid at the phase of cephalosporin synthesis was played by the other enzyme i. e. glutamate dehydrogenase. By the dynamics the curve of the glutamate dehydrogenase activity correlated with that of the antibiotic production.
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