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  • Title: Dose-dependent mortality involving convulsions due to subarachnoid Urografin® injection in rats.
    Author: Shimada R, Ezaki J, Kibayashi K.
    Journal: Leg Med (Tokyo); 2017 Nov; 29():29-33. PubMed ID: 29017086.
    Abstract:
    An ionically hypertonic contrast medium Urografin® was inadvertently administered into the subarachnoid space of an individual and this resulted in convulsions and acute respiratory failure. We examined the effects of subarachnoid Urografin® injections on the rat central nervous system. The onset and frequency of the convulsions, as well as fatality, were dependent on the amount of Urografin® administered. No convulsions were observed in rats receiving injections of hypertonic NaCl solution or saline. The results confirmed that subarachnoid injections of Urografin® cause convulsions and death, as previously reported in human cases, and our study ascertained the causal relationship between the above malpractice and fatal outcomes.
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