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  • Title: Import of proteins into mitochondria.
    Author: Eilers M, Verner K, Hwang S, Schatz G.
    Journal: Philos Trans R Soc Lond B Biol Sci; 1988 May 31; 319(1193):121-6. PubMed ID: 2901761.
    Abstract:
    A mounting body of evidence suggests that cytoplasmically synthesized proteins destined to be imported into the mitochondrial interior must at least partly unfold to penetrate across the mitochondrial membranes. During post-translational import, this unfolding process appears to be a major rate-limiting step. It can be blocked by ligands that stabilize the protein's native conformation and appears to be accompanied by the cleavage of ATP outside the mitochondrial inner membrane.
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