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  • Title: Emerging Insights into Noncanonical Inflammasome Recognition of Microbes.
    Author: Russo AJ, Behl B, Banerjee I, Rathinam VAK.
    Journal: J Mol Biol; 2018 Jan 19; 430(2):207-216. PubMed ID: 29017836.
    Abstract:
    Inflammasomes are cytosolic multi-molecular complexes that sense intracellular microbial danger signals and metabolic perturbations. Inflammasome activation leads to the activation of caspase-1 and the release of pro-inflammatory cytokines IL-1β and IL-18 accompanied by cell death. An inflammasome-based surveillance machinery for Gram-negative bacterial infections has been recently discovered. This noncanonical inflammasome relies on sensing the cytosolic presence of lipopolysaccharide of Gram-negative bacteria via inflammatory caspases such as caspase-4, -5, and -11. This review discusses the recent findings related to the mechanism of activation of the noncanonical inflammasome and its biological functions.
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