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  • Title: Role of the route of leukotrienes in an experimental model of oral mucositis induced by 5-fluorouracil 1.
    Author: Silva VCD, Leitão RFC, Brito GAC, Martins CDS, Freire GE, Aragão KS, Wanderley CWS, Freitas MR.
    Journal: Acta Cir Bras; 2017 Sep; 32(9):712-725. PubMed ID: 29019589.
    Abstract:
    PURPOSE: To investigate the participation of cysteinyl leukotrienes in the pathophysiology of oral mucositis. METHODS: Oral mucositis was induced in hamsters using 5-fluorouracil (5-FU; 60 and 40 mg/kg; i.p., on days 1 and 2, respectively, and with excoriations in jugal mucosa on day 4). Montelukast (10, 20, or 40 mg/kg/d; gavage), MK886 (3 mg/kg/d, i.p.), or saline or celecoxib (7.5 mg/kg/d; i.p.) was administered 1 h prior to 5-FU and daily, until the fourth (MK886) or tenth day, when the animals were euthanized and their jugal mucosa was collected for macroscopic, histopathological, and immunohistochemical evaluation. RESULTS: Neither montelukast nor MK-886 prevented the oral mucositis induced by 5-FU, as observed by histopathological evaluation. In addition, we did not find significant differences in the expression of inducible nitric oxide synthase-2, cyclooxygenase-2, or interleukin (IL)-1β between the experimental and control groups. However, we did observe a significant decrease in tumor necrosis factor (TNF)-α expression for all doses of montelukast; we also observed a significant decrease in IL-10 with 40 mg/kg/d and MK 886. CONCLUSIONS: Cysteinyl leukotrienes do not play an important role in experimental oral mucositis induced by 5-FU. There is a modulating action specifically on TNF-α.
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