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  • Title: Heterometal-Coordinated Monomeric Concanavalin A at pH 7.5 from Canavalia ensiformis.
    Author: Chung NJ, Park YR, Lee DH, Oh SY, Park JH, Lee SJ.
    Journal: J Microbiol Biotechnol; 2017 Dec 28; 27(12):2241-2244. PubMed ID: 29025256.
    Abstract:
    The structure of concanavalin A (ConA) has been studied intensively owing to its specific interactions with carbohydrates and its heterometal (Ca²⁺ and Mn²⁺) coordination. Most structures from X-ray crystallography have shown ConA as a dimer or tetramer, because the complex formation requires specific crystallization conditions. Here, we reported the monomeric structure of ConA with a resolution of 1.6 Å, which revealed that metal coordination could trigger sugar-binding ability. The calcium coordination residue, Asn14, changed the orientation of carbohydrate-binding residues and biophysical details, including structural information, providing valuable clues for the development and application of detection kits using ConA.
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