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  • Title: 3-Methylcholanthrene does induce mixed function oxidase activity in hepatopancreas of spiny crab Maja crispata.
    Author: Batel R, Bihari N, Zahn RK.
    Journal: Comp Biochem Physiol C Comp Pharmacol Toxicol; 1988; 90(2):435-8. PubMed ID: 2903003.
    Abstract:
    1. Type II inducers (7,8-benzoflavone, benzo(a)-pyrene and 3-methylcholanthrene) as well as Aroclor 1254, significantly increase benzo(a)pyrene monooxygenase activity in crab hepatopancreas while type I inducer (phenobarbital) does not enhance benzo(a)pyrene monooxygenase activity. 2. 3-methylcholanthrene and benzo(a)pyrene treatment of crabs significantly increase cytochrome P-450 content. 3. Benzo(a)pyrene monooxygenase induction in hepatopancreas of 3-methylcholanthrene treated crabs was inhibited by simultaneous treatment with cycloheximide but not by actinomycin D. 4. Actinomycin D insensitivity can be explained involving a regulatory pattern of induction on the posttranscriptional and/or translational, rather than transcriptional level.
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