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  • Title: In vitro enhancement of human platelet aggregation by somatostatin.
    Author: Gazzaniga PP, Di Macco G, La Mancusa R, Oddi A, Pappalardo G, Pulcinelli FM, Reggio D.
    Journal: Experientia; 1988 Oct 15; 44(10):892-4. PubMed ID: 2903069.
    Abstract:
    Very low concentrations of somatostatin (S-14) strongly potentiate the in vitro aggregation induced by collagen, ristocetin and arachidonic acid, but not that induced by ADP or epinephrine, in both human platelet rich plasmas and gel-filtered platelet preparations. Desensitization phenomena may be induced either by repeated addition of S-14 or long lasting contact between S-14 and platelets.
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