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  • Title: Inhibitory effect of taurolipids on Clostridium perfringens sialidase.
    Author: Nohara-Uchida K, Kaya K.
    Journal: J Biochem; 1988 May; 103(5):840-2. PubMed ID: 2903144.
    Abstract:
    Taurolipids A and B, which are detergent-type compounds isolated from protozoan Tetrahymena cells, were demonstrated to inhibit strongly the activity of Clostridium perfringens sialidase. On addition of 280 pmol of taurolipid B to 20 mU of the enzyme, the sialidase activity was decreased to 7% of the original activity at pH 5.1 as the optimum pH. The inhibition was non-competitive. Effective inhibition was observed at the acidic region from the isoelectric point of the sialidase, and at a low ionic strength. Both the long chain acyl and sulfonic acid groups of taurolipids were required for the inhibition of the sialidase activity. A mechanism is postulated for the inhibition.
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