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  • Title: Protracted tinnitus after discontinuation of long-term therapeutic use of benzodiazepines.
    Author: Busto U, Fornazzari L, Naranjo CA.
    Journal: J Clin Psychopharmacol; 1988 Oct; 8(5):359-62. PubMed ID: 2903182.
    Abstract:
    The presence of protracted tinnitus after discontinuation of long-term therapeutic doses of diazepam (less than or equal to 30 mg/day) is described in three patients. In one of these patients, the association of the tinnitus appearance with the drug discontinuation was documented in a double-blind, randomized, crossover single case study. Objective confirmation of drug use or of abstinence was performed by obtaining plasma benzodiazepine concentrations. The findings provide further documentation that sensory disturbances of short- and long-term duration are among the most distinctive clinical features of the benzodiazepine withdrawal syndrome.
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