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  • Title: A light-up probe targeting for Bcl-2 2345 G-quadruplex DNA with carbazole TO.
    Author: Gu Y, Lin D, Tang Y, Fei X, Wang C, Zhang B, Zhou J.
    Journal: Spectrochim Acta A Mol Biomol Spectrosc; 2018 Feb 15; 191():180-188. PubMed ID: 29032342.
    Abstract:
    As its significant role, the selective recognition of G-quadruplex with specific structures and functions is important in biological and medicinal chemistry. Carbazole derivatives have been reported as a kind of fluorescent probe with many excellent optical properties. In the present study, the fluorescence of the dye (carbazole TO) increased almost 70 fold in the presence of bcl-2 2345 G4 compared to that alone in aqueous buffer condition with almost no fluorescence and 10-30 fold than those in the presence of other DNAs. The binding study results by activity inhibition of G4/Hemin peroxidase experiment, NMR titration and molecular docking simulation showed the high affinity and selectivity to bcl-2 2345 G4 arises from its end-stacking interaction with G-quartet. It is said that a facile approach with excellent sensitive, good selectivity and quick response for bcl-2 2345 G-quadruplex was developed and may be used for antitumor recognition or antitumor agents.
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