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  • Title: Inhibition of rumination in sheep by alpha-adrenoreceptor antagonists.
    Author: Nicholson T, Osman TE, Belkhiri M.
    Journal: J Vet Pharmacol Ther; 1988 Sep; 11(3):276-82. PubMed ID: 2903255.
    Abstract:
    Rumination activity was recorded in sheep during a period of 3 h. The amount of rumination occurring in 30 min following the intravenous injection of an alpha 1 blocking drug (prazosin, 0.1 mg/kg) and an alpha 2 blocking drug (idazoxan, 0.1 mg/kg) was reduced compared with control days when saline was given. The observation that rumination can be stimulated by a rapid, intravenous dose of adrenalin was confirmed. The induction of rumination by adrenalin was prevented by these alpha-adrenoreceptor antagonists given singly or together at the dose rate mentioned. These findings are discussed in the light of knowledge that normal reticulo-ruminal motility and food intake can be inhibited by stimulation of alpha 2-adrenoreceptors.
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