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  • Title: Eluxadoline in the treatment of diarrhea-predominant irritable bowel syndrome.
    Author: Özdener AE, Rivkin A.
    Journal: Drug Des Devel Ther; 2017; 11():2827-2840. PubMed ID: 29033544.
    Abstract:
    Eluxadoline is a novel drug approved for the management of diarrhea predominant irritable bowel syndrome (IBS-D). It has unique pharmacology and works on three different opioid receptors. Several Phase II and III clinical trials have demonstrated eluxadoline's efficacy in reducing symptoms related to IBS-D. Clinical trial results and postmarketing reports show a risk of pancreatitis in patients without a gallbladder or those abusing alcohol. This review article will include information on clinical trial results related to IBS-D management as well as eluxadoline's limitations.
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