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  • Title: Response to drugs in schizophrenia: the influence of family history, obstetric complications and ventricular enlargement.
    Author: Nimgaonkar VL, Wessely S, Tune LE, Murray RM.
    Journal: Psychol Med; 1988 Aug; 18(3):583-92. PubMed ID: 2903512.
    Abstract:
    A prospective study of antipsychotic drug treatment showed no difference in response between schizophrenic in-patients with or without a familial predisposition to the illness (N = 53). All patients received at least 600 mg chlorpromazine equivalents antipsychotic medication for 6 weeks. Ventricle brain ratios, ratings of cortical sulcal widening and a history of obstetric complications also failed to account for the variability, but early age of onset was associated with unsatisfactory response.
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