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  • Title: Cytotoxic Dibohemamines D-F from a Streptomyces Species.
    Author: Jiang B, Zhao W, Li S, Liu H, Yu L, Zhang Y, He H, Wu L.
    Journal: J Nat Prod; 2017 Oct 27; 80(10):2825-2829. PubMed ID: 29035560.
    Abstract:
    Three dimeric analogues of bohemamines, dibohemamines D-F (1-3), together with dibohemamine A (4), were isolated from Streptomyces sp. CPCC 200497. Their structures were solved using a combination of mass spectrometry, 1D and 2D NMR spectroscopy, and CD. Dibohemamines D and E were new dimeric analogues of bohemamines, and dibohemamine F was a known compound obtained previously by semisynthesis. Dibohemamine F displayed potent cytotoxicity against cancer cell lines A549 and HepG2 with IC50 values of 1.1 and 0.3 μM, respectively. Dibohemamines D and E showed moderate cytotoxicity against cancer cell lines A549 and HepG2.
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