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  • Title: Recent advances in production of 5-aminolevulinic acid using biological strategies.
    Author: Kang Z, Ding W, Gong X, Liu Q, Du G, Chen J.
    Journal: World J Microbiol Biotechnol; 2017 Oct 16; 33(11):200. PubMed ID: 29038905.
    Abstract:
    5-Aminolevulinic acid (5-ALA) is the precursor for the biosynthesis of tetrapyrrole compounds and has broad applications in the medical and agricultural fields. Because of the disadvantages of chemical synthesis methods, microbial production of 5-ALA has drawn intensive attention and has been regarded as an alternative in the last years, especially with the rapid development of metabolic engineering and synthetic biology. In this mini-review, recent advances on the application and microbial production of 5-ALA using novel biological approaches (such as whole-cell enzymatic-transformation, metabolic pathway engineering and cell-free process) are described and discussed in detail. In addition, the challenges and prospects of synthetic biology are discussed.
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