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  • Title: Azelastine inhibits bronchial hyperreactivity to acetylcholine in guinea pigs.
    Author: Achterrath-Tuckermann U, Szelenyi I.
    Journal: Experientia; 1988 Dec 01; 44(11-12):993-6. PubMed ID: 2904378.
    Abstract:
    Contractile responses to acetylcholine were measured using isolated tracheae obtained from actively sensitized guinea pigs 0.5, 1, 5, 20, 24, 48 and 72 h after antigen challenge. Tracheal contractions to acetylcholine and to histamine were significantly increased 20 h but not 0.5, 1, 5, 24, 48 and 72 h after antigen challenge indicating bronchial hyperreactivity. When animals were pretreated with azelastine and then exposed to antigen challenge, concentration-response curve to acetylcholine did not differ from that obtained in control (non-challenged) tracheae. It is likely that azelastine is able to inhibit bronchial hyperresponsiveness to chemical mediators of bronchial asthma.
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