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  • Title: Correlation of the ultrasound imaging of breast cancer and the expression of molecular biological indexes.
    Author: Xu J, Li F, Chang F.
    Journal: Pak J Pharm Sci; 2017 Jul; 30(4(Suppl.)):1425-1430. PubMed ID: 29043992.
    Abstract:
    This paper aims to 137 cases of breast malignant tumors confirmed by surgery and pathology were collected. All patients received ultrasound examination and were not treated by radiotherapy or chemotherapy before operation. The preoperative ultrasound images of breast cancer patients and postoperative pathological characteristics of paraffin sections were retrospectively observed. Ultrasound indicators included tumor size, shape, ratio of the longest/shortest dimension, edge of the spiculation and peripheral hyperechoic halo sign, internal echo types, micro calcification, posterior echo types, blood flow and signs of lymph node metastasis. The pathological indexes included histological type, infiltrating ductal carcinoma (IDC), histological grading, cancer tissue in the interior and edge of the lesion and stroma and expression of molecular biology indexes (ER, PR and C-erbB-2). The correlation of ultrasound imaging of breast cancer and his to pathological type and grading were analyzed and the ultrasounic characteristics and the his to pathological features was compared; then to explore the correlation of ultrasonic imaging of breast cancer and the expression of ER, PR and C-erbB-2. the tumor size of IDC (>2cm) was lager than that of the ductal carcinoma in situ (DCIS) and the early-stage IDC, with statistical significance (P<0.05), but compared with the specific carcinoma of breast (P>0.05). The ratio of irregular mass of IDC was more than that of the specific carcinoma of breast (P<0.05), but without statistical significance compared with the DCIS and early-stage IDC (P>0.05). The spiculate margin in the IDC was more than that of the early-stage IDC, DCIS and specific carcinoma of breast (P>0.05). The ratio of the longest/ shortest dimension, peripheral hyperechoic halo sign, internal echo, micro calfication, posterior echo types were not related to the types of breast cancer (P>0.05). The irregular mass rate in the III IDC were much higher than that in the I and II level IDC (P>0.05). The posterior echo attenuation in the I IDC was much higher than the II and III IDC (P>0.05). The tumor size, spiculate margin, peripheral hyperechoic halo, internal echo types, micro calcification were not significantly related to the histological grading of IDC. The tumor with larger size (>2cm), enhanced posterior echo, or lower internal echo will have a high histological classification and high rate of cancer tissue (P<0.05). The tumor with enhanced peripheral hyperechoic halo sign will have a higher histological classification and higher rate of cancer tissue in the peripheral tissues, compared with the tumors without halo (P<0.05). The tumor shape, ratio of the longest/ shortest dimension, spiculate margin were not significantly related to the internal tissues (P>0.05). The ratio of the longest/ shortest dimension (>1), spiculate margin and halo signs were related to the positive expression of ER and PR (P<0.05). The internal necrosis was related to the negative expression of PR, (P<0.05). The tumor size, shape, posterior echo types and blood flow were not significantly related to the expression of ER, PR and C-erbB-2 (P>0.05).
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