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  • Title: A highly conserved sequence on the short arm of chromosome 7 detects multiple polymorphisms.
    Author: Bardoni B, Guioli S, Maserati E, Maraschio P, Camerino G.
    Journal: Hum Genet; 1988 Dec; 81(1):23-5. PubMed ID: 2904403.
    Abstract:
    We have isolated a human DNA fragment (laboratory acronym G98) that detects related sequences in mammals, chicken and Drosophila DNAs. This sequence has been mapped to human chromosome 7 p14-p15 by in situ hybridization. Probe G98 recognizes an insertion-deletion type polymorphism, with allelic frequencies of about 0.5, which can be detected with at least six different restriction enzymes. A second polymorphism, which can be detected in human DNA digested with TaqI, is in non-complete linkage disequilibrium with the first polymorphism. About 70% of the individuals analysed have been found to be heterozygous at this locus.
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