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  • Title: Effects of angiotensin II on isolated toad (Bufo arenarum) aortic rings.
    Author: Peral de Bruno M, Lebenshon de Chialvo P, Coviello A.
    Journal: Comp Biochem Physiol C Comp Pharmacol Toxicol; 1988; 90(1):195-201. PubMed ID: 2904859.
    Abstract:
    1. The vascular response to Asn1-Val5 angiotensin II (A II) in aortic rings from Bufo arenarum toad was studied. 2. Tachyphylaxis in response to A II could be abolished after incubation with norepinephrine (NE). 3. Phentolamine treatment partially inhibited the pressor effects to A II. 4. Sar1-Ile8 A II and Sar1-Ala8 A II significantly attenuated the vascular effects of A II and did not affect the NE response. 5. We conclude that the pressor response to A II has a direct contractile effect and a catecholamine dependent component in aortic rings of Bufo arenarum toad.
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