These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Substrate recognition by two different P450s: Evidence for conserved roles in a common fold.
    Author: Tietz DR, Colthart AM, Sondej Pochapsky S, Pochapsky TC.
    Journal: Sci Rep; 2017 Oct 19; 7(1):13581. PubMed ID: 29051575.
    Abstract:
    Cytochrome P450 monooxygenases CYP101A1 and MycG catalyze regio- and stereospecific oxidations of their respective substrates, d-camphor and mycinamicin IV. Despite the low sequence homology between the two enzymes (29% identity) and differences in size and hydrophobicity of their substrates, the conformational changes that occur upon substrate binding in both enzymes as determined by solution NMR methods show some striking similarities. Many of the same secondary structural features in both enzymes are perturbed, suggesting the existence of a common mechanism for substrate binding and recognition in the P450 superfamily.
    [Abstract] [Full Text] [Related] [New Search]