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  • Title: Differential effects of EEDQ on the dopamine D-1 receptor in vivo and in vitro.
    Author: Andersen PH.
    Journal: Eur J Pharmacol; 1988 Jul 26; 152(1-2):153-6. PubMed ID: 2905267.
    Abstract:
    As measured in vitro by means of [3H]SCH 23390 saturation analysis, 5 and 10 mg/kg (i.p., 24 h) of EEDQ caused a 70% reduction and 20 mg/kg and 80% reduction in the numbers of D-1 receptors. In vivo, also measured by [3H]SCH 23390 saturation analysis, 5 mg/kg of EEDQ caused no significant reduction in the D-1 receptor number whereas 10 and 20 mg/kg caused a 40 and 70% reduction, respectively. This difference in sensitivity to EEDQ in vivo as compared to in vitro suggests that EEDQ only destabilizes the D-1 receptor, whereas the inactivation occurs during preparation of the tissue for in vitro binding. Thus, caution should be exercised when animals depleted of D-1 receptors by EEDQ are used for behavioral studies.
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