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  • Title: Estimation of intake and uptake of bisphenols and triclosan from personal care products by dermal contact.
    Author: Lu S, Yu Y, Ren L, Zhang X, Liu G, Yu Y.
    Journal: Sci Total Environ; 2018 Apr 15; 621():1389-1396. PubMed ID: 29054660.
    Abstract:
    Increasing concern has been raised in respect of exposure to bisphenols and triclosan (TCS) due to their widespread use. However, little is known about their occurrence in personal care products (PCPs) or, particularly, their dermal uptake following daily application. It is therefore necessary to evaluate the human health risk of bisphenols and TCS via dermal absorption. In this study, 150 PCPs, covering 11 different categories, were collected in China. The concentrations of seven bisphenol analogues and TCS were measured, and the associated human health risks by dermal contact were estimated. High detection frequencies of TCS (46.7%) and bisphenol AF (38.7%) were found in the PCPs. The highest mean concentration of Σ7BPs (sum concentration of all seven bisphenols) was 77.8ngg-1 found in masks, and the highest mean concentration of TCS was 86.7ngg-1 in hand sanitizers. The bisphenol composition profiles varied among different categories. Bisphenol A and bisphenol F generally showed higher concentrations. Combining the concentrations of the target substances with the daily usage quantities of PCPs and other parameters, the total estimated dermal intakes and uptakes of Σ7BPs and TCS were calculated. The results showed that the former (12.1 and 1.06ng·kg-1bwday-1) were markedly higher than the latter (1.21 and 9.58×10-2ng·kg-1bwday-1), which included dermal absorption rates of the chemicals in the estimation. Although diet is the main source, and oral ingestion is the main route, for human BPA exposure, the results of the estimated dermal uptakes of BPA in the present study combined with those from a European study show that dermal contact is the main route with thermal paper being the main contributor when both unconjugated and conjugated BPA in the human body are considered. The present study also showed that exposure to BPA in PCPs following dermal contact should not be ignored.
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