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  • Title: [The alpha-adrenergic sensitivity of smooth muscle following sympathectomy].
    Author: Telina EN, Khamitov KhS, Akhmedzianov RKh.
    Journal: Fiziol Zh SSSR Im I M Sechenova; 1988 Sep; 74(9):1287-93. PubMed ID: 2905677.
    Abstract:
    The effect of sympathetic nerve stimulation on postsynaptic alpha-adrenoceptors of cat's smooth muscle nictitating membrane was studied. L-noradrenaline, adrenaline, phenylephrine and clonidine caused a concentration-dependent contraction. In denervated tissue, the concentration-response curve for clonidine mainly shifted to the left in comparison with the control; in contrast to the innervated smooth muscle, there were no reliable differences between the constant dissociation Ka and KB for alpha 1- and alpha 2-selective and nonselective adrenomimetics and adrenoblockaders. The data obtained suggest alteration of pharmacological characteristics of smooth muscle alpha-adrenoceptors after interruption of the sympathetic nerve.
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