These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Restriction endonuclease analysis of leukocyte mitochondrial DNA in Leber's optic atrophy.
    Author: Holt IJ, Miller DH, Harding AE.
    Journal: J Neurol Neurosurg Psychiatry; 1988 Aug; 51(8):1075-7. PubMed ID: 2905730.
    Abstract:
    In order to test the hypothesis that Leber's optic atrophy may be caused by mutation of the mitochondrial (mt) genome, restriction fragment length polymorphism in leukocyte mt DNA was studied in 16 patients with Leber's optic atrophy, 28 of their unaffected matrilineal relatives, and 35 normal control subjects. No differences in restriction fragment patterns were observed between affected and unaffected individuals in the same maternal line, and there was no evidence of major deletion of mt DNA in patients. This study provides no positive evidence of mitochondrial inheritance in Leber's optic atrophy but does not exclude it.
    [Abstract] [Full Text] [Related] [New Search]