These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Enzymuria following administration of contrast media in hypertensive rats].
    Author: Wrigge P, Mályusz M.
    Journal: Rontgenblatter; 1988 Aug; 41(8):332-5. PubMed ID: 2905826.
    Abstract:
    Renal complications may occur in risk patients with pre-existing kidney damage if x-ray contrast media are administered. Nothing is known of the exact mechanisms of these reactions. We examined in rats with long-term renovascular hypertension and resulting nephrosclerosis the low osmolar contrast media ioxaglate, iohexol and iopamidol in respect of their renal tolerance compared with an osmotically equivalent mannite solution. Under the conditions of intravenous pyelography, we observed directly after the administration of all substances (3.5 mg/kg body weight) an enhanced enzymuria of gamma-glutamyl transpeptidase and N-acetyl-beta-D-glucosaminidase. The loss of enzyme is mainly due to the osmotic effect of the preparations. The nonionic contrast media iohexol and iopamidol produce a slighter enzymuria than the ionic ioxaglate.
    [Abstract] [Full Text] [Related] [New Search]