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  • Title: Assessment of effects of amino acids and branched chain keto acids on leucine oxidation in human lymphocytes.
    Author: Schäfer G, Schauder P.
    Journal: Scand J Clin Lab Invest; 1988 Oct; 48(6):531-6. PubMed ID: 2905828.
    Abstract:
    Effects of amino acids and branched chain keto acids on leucine transamination and oxidation were assessed in peripheral human lymphocytes. Isoleucine (80-200 mumol/l) and valine (250-500 mumol/l) diminished transamination and oxidation of leucine up to 25%, glutamine (50-1000 mumol/l) up to 55%. alpha-Ketoisocaproic acid (KIC; 200 mumol/l) augmented the activity state of branched chain keto acid dehydrogenase by 40%. It is concluded that in peripheral human lymphocytes (1) isoleucine, valine and glutamine are physiological inhibitors of leucine catabolism, and (2) leucine can promote its own degradation via KIC.
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