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  • Title: Stimulation of NMDA receptors induces proteolysis of spectrin in hippocampus.
    Author: Seubert P, Larson J, Oliver M, Jung MW, Baudry M, Lynch G.
    Journal: Brain Res; 1988 Sep 13; 460(1):189-94. PubMed ID: 2905922.
    Abstract:
    Stimulation of N-methyl-D-aspartate (NMDA) receptors was found to induce proteolysis of brain spectrin in hippocampal slices. The effect was dependent upon extracellular calcium, blocked by the antagonist 2-amino-5-phosphonovalerate (AP5), and was not reproduced by potassium-induced depolarization. These results are consistent with the hypothesis that the involvement of NMDA receptors in plasticity and excitotoxicity is at least partially mediated by calcium-activated proteolysis of cytoskeletal proteins.
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