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  • Title: Guaianolide sesquiterpene lactones and aporphine alkaloids from the stem bark of Guatteria friesiana.
    Author: Costa EV, Soares LN, Pinheiro MLB, Maia BHLNS, Marques FA, Barison A, Almeida JRGS, Sousa IL, Galaverna RS, Heerdt G, Morgon NH, Acho LDR, Lima ES, da Silva FMA, Koolen HHF.
    Journal: Phytochemistry; 2018 Jan; 145():18-25. PubMed ID: 29059536.
    Abstract:
    Three guaianolide sesquiterpenes, denoted guatterfriesols A-C, and four aporphine alkaloid derivatives were isolated from the stem bark of the Amazonian plant Guatteria friesiana. Thus far, sesquiterpene lactones have not been described in Annonaceae. Structures of the previously undescribed compounds were established by using 1D and 2D NMR spectroscopy in combination with MS. The absolute stereochemistry was assigned via NOE NMR experiments, ECD spectroscopy, and theoretical calculations using the TDDFT approach. Among the isolated compounds, the alkaloid guatterfriesidine showed anti-glycation activity by inhibiting the formation of advanced glycation end-products (AGEs) through the prevention of oxidation in both BSA/methylglyoxal and BSA/fructose systems.
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