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  • Title: CHOP regimen versus intermittent chlorambucil-prednisone in stage B chronic lymphocytic leukemia. Short term results from a randomized clinical trial. French Cooperative Group on Chronic Lymphocytic Leukemia.
    Journal: Nouv Rev Fr Hematol (1978); 1988; 30(5-6):449-52. PubMed ID: 2906118.
    Abstract:
    In 1985, the French Cooperative Group on Chronic Lymphocytic Leukemia started a protocol based on the (A, B, C) staging system. This paper reports the first interim results in stage B patients who were randomized to receive either the CHOP regimen or intermittent chlorambucil plus prednisone. Out of the 199 stage B patients, randomized on the reference date of May 1 1988, 94 received chlorambucil plus prednisone (7 deaths) and 105 the CHOP regimen (6 deaths). Among the evaluable patients at the 6-month examination, 53% reached clinical remission or stage A in the chlorambucil-prednisone group while 77% died in the CHOP group (p = 0.002). This short-term result supports the effectiveness of the CHOP regimen previously demonstrated by group in stage C patients. More follow-up is needed to assess the benefit from the CHOP regimen in terms of survival in stage B patients.
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