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  • Title: Retromer revisited: Evolving roles for retromer in endosomal sorting.
    Author: Chamberland JP, Ritter B.
    Journal: J Cell Biol; 2017 Nov 06; 216(11):3433-3436. PubMed ID: 29061649.
    Abstract:
    The highly conserved retromer complex has been linked to cargo retrieval from endosomes to the trans-Golgi network. In this issue, Kvainickas et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201702137) and Simonetti et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201703015) fundamentally question the current retromer model and demonstrate that in mammalian cells, the individual retromer subcomplexes have functionally diverged to organize multiple distinct sorting pathways.
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