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  • Title: A new lormetazepam galenical formulation for sublingual premedication.
    Author: Van Boven MJ, Scholtes JL, Collard E, Van Obbergh L, Gribomont BF.
    Journal: Acta Anaesthesiol Belg; 1988; 39(4):233-7. PubMed ID: 2906778.
    Abstract:
    This study reports a double-blind evaluation of a new formulation of lormetazepam for sublingual administration, given as a premedicant in 48 female patients undergoing minor gynecological procedures. Both patient's and nurse's assessments for anxiety and sedation were recorded at different times. Anxiolysis and sedation were present 30 minutes after administration of the drug as reported by the patient with a peak effect at 45 minutes. Nurses reported significant differences in sedation only, but already present at 30 minutes after premedication. The memory test showed no persistent effect of the benzodiazepine one day after surgery.
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