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  • Title: Unguiculins A-C: cytotoxic bis-guanidine alkaloids from the French Polynesian sponge, Monanchora n. sp.
    Author: El-Demerdash A, Moriou C, Martin MT, Petek S, Debitus C, Al-Mourabit A.
    Journal: Nat Prod Res; 2018 Jul; 32(13):1512-1517. PubMed ID: 29067835.
    Abstract:
    Two new acyclic bis-guanidine alkaloids, unguiculins B-C (2-3), were isolated from a French Polynesian sponge Monanchora n. sp. together with the known compound unguiculin A (1). Their structures were established by spectroscopic data interpretation and comparison with the literature. Unguiculins A-C displayed antiproliferative and cytotoxic efficacy against several human cancer cells with IC50 values in the micromolar range.
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