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  • Title: Intestinal absorption of cephalosporin antibiotics: correlation between intestinal absorption and brush-border membrane transport.
    Author: Hori R, Okano T, Kato M, Maegawa H, Inui K.
    Journal: J Pharm Pharmacol; 1988 Sep; 40(9):646-7. PubMed ID: 2907034.
    Abstract:
    The absorption of seven cephalosporin antibiotics from the in-situ intestinal loop at pH 7.4 and their transport by brush-border membrane vesicles in the presence of an inward H+ gradient ([pH]i = 7.5, [pH]o = 6.0) were examined. A good correlation was found between the intestinal absorption rate and the initial uptake rate by brush-border membrane vesicles. The data suggest that the transport study using intestinal brush-border membrane vesicles is useful as a model system for the intestinal absorption of beta-lactam antibiotics.
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