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  • Title: [Effectiveness of Electroacupuncture of Zigong (EX-CA 1), etc. in Treatment of Perimenopausal Syndrome Women].
    Author: Liu XR, Zang ZW, Li XL, Ma JH.
    Journal: Zhen Ci Yan Jiu; 2016 Jun 25; 41(3):247-50. PubMed ID: 29071914.
    Abstract:
    OBJECTIVE: To evaluate the curative effect of electroacupuncture(EA) of Zigong (EX-CA 1) and Tianshu (ST 25) and acupuncture of Sanyinjiao (SP 6) and Guanyuan (CV 4) for perimenopausal syndrome(PMS). METHODS: Fifty-eight PMS patients were equally and randomized into acupuncture group and medication group. EA (10 Hz/50 Hz, 30 min in duration) was applied at Zigong (EX-CA 1) and Tianshu (ST 25) in combination with manual acupuncture stimulation of Sanyinjiao (SP 6) and Guanyuan (CV 4) by twirling the acupuncture needles with small amplitude and till deqi. The treatment was conducted once every other day, three times a week, 8 weeks altogether. The patients of the medication group were asked to take estradiol valerate (1 mg/time, qd) for 3 weeks, then, to have one week's rest and continuously took estradiol valerate(1 mg/d) and medroxyprogesterone 17-acetate (8 mg/d) for 10 days. The therapeutic effects were assessed by Menopause Rating Scale Questionnaire[MRS, composing of 3 areas:somatic (4 items), psychological(4 items) and urogenital (3 items) domain]. Serum estradiol (E2), follicle stimulating hormone(FSH) and luteotrophic hormone (LH) contents were assayed using ELISA. RESULTS: After the treatment, the scores of the MRS and the contents of serum FSH and LH were significantly decreased in both the acupuncture and medication groups (P<0.01), and serum E2 contents significantly increased in the two groups (P<0.01). No significant differences were found between the two groups in the total effective rates (P>0.05). Eight weeks' follow-up showed that the MRS score of the acupuncture group was significantly lower than that of the medication group (P<0.05). Of the two 29 PMS patients in the medication and acupuncture groups, 3 (10.3%) and 2 (6.9%) cases were under control, 22 (75.9%) and 21 (72.4%) experienced a marked improvement in their symptoms, 3 (10.3%) and 4(13.8%) were effective, 1 (3.4%) and 2(6.9%) invalid, with the effective rates being 96.6% and 93.1%, respectively. Eight weeks' follow-up showed that the long-term effect of the acupuncture therapy was obviously superior to that of the medication (P<0.05) according to MRS score. CONCLUSIONS: Acupuncture therapy is effective in relieving clinical symptoms of PMS women by regulating endocrine hormones, being similar to medication.
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