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  • Title: Toxic delirium after L-dopa medication.
    Author: Birkmayer W.
    Journal: J Neural Transm Suppl; 1978; (14):163-6. PubMed ID: 290736.
    Abstract:
    L-DOPA-psychosis is a frequent side effect of the combined treatment of Parkinson's disease with L-DOPA and peripherally active decarboxylase inhibitors. Regional human post-mortem brain studies showed a significant increase of noradrenaline and serotonin particularly in extrastriatal areas, whereas the lenticular nuclei were not involved. The significance of extrastriatal neurotransmitter dysfunctions for psychiatric disorders is discussed.
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