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  • Title: Propranolol in the preoperative treatment of Kasabach-Merritt syndrome: a case report.
    Author: Radović SV, Kolinović M, Ljubić D.
    Journal: J Med Case Rep; 2017 Oct 27; 11(1):308. PubMed ID: 29073926.
    Abstract:
    BACKGROUND: Kasabach-Merritt syndrome represents the association of hemangioma with thrombocytopenia and consumptive coagulopathy. We present a case of Kasabach-Merritt syndrome treatment with orally administered propranolol. CASE PRESENTATION: A 4.5-month-old caucasian female infant with congenital giant hemangioma in the posterior region of her neck presented to our Institute for Childhood Diseases where she underwent clinical, laboratory, and radiological investigations. A low blood platelet count indicated the use of corticosteroids and blood components as first-line therapy. The lack of therapeutic response induced the introduction of orally administered propranolol as additive therapy. A 3-week treatment led to a reduction in the size of hemangioma and a rise in platelet count which enabled surgical treatment and definite healing. CONCLUSION: Orally administered propranolol as monotherapy or in combination with other therapeutic modalities may play a key role in the treatment of Kasabach-Merritt syndrome.
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