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  • Title: Characterization of methamphetamine effects on the striatal-nigral dynorphin system.
    Author: Hanson GR, Merchant KM, Letter AA, Bush L, Gibb JW.
    Journal: Eur J Pharmacol; 1988 Oct 11; 155(1-2):11-8. PubMed ID: 2907484.
    Abstract:
    Multiple high doses of methamphetamine (METH) induced 200-300% increases in the concentration of striatal and nigral dynorphin-like immunoreactivity (DLI). Increases in striatal and nigral DLI levels also were seen within 6 h following a single administration. The changes in the striatal-nigral dynorphin system had subsided 48 h after either acute or multiple treatments with METH. Selective lesioning of the nigral-striatal dopamine pathway blocked the effects; thus, the METH-induced changes appeared to be mediated by dopamine released from the nigral-striatal dopamine projection. Administration of the METH analog, 3,4-methylenedioxymethamphetamine, appeared to alter striatal and nigral DLI concentrations in a manner similar to that of METH.
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