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Title: Equilibrium binding of spermine and histamine to salmon sperm DNA and poly(dGdC). Author: Winkle SA, Crooks PA. Journal: J Pharm Pharmacol; 1988 Nov; 40(11):809-11. PubMed ID: 2907565. Abstract: Studies using the solute-enhanced phase partition technique demonstrate that the endogenous amines histamine and spermine bind to both salmon sperm DNA and poly(dGdC) in a markedly cooperative fashion. Both compounds exhibited DNA sequence-dependence effects in their mode of binding. The linear aliphatic spermine molecule binds more strongly than histamine to both DNA types.[Abstract] [Full Text] [Related] [New Search]