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  • Title: Comparative cost and clinical effectiveness of clostridial collagenase ointment for chronic dermal ulcers.
    Author: Waycaster C, Carter MJ, Gilligan AM, Mearns ES, Fife CE, Milne CT.
    Journal: J Comp Eff Res; 2018 Feb; 7(2):149-165. PubMed ID: 29076747.
    Abstract:
    Chronic dermal ulcers affect approximately 2.4-4.5 million people in the USA and are associated with loss of function, decreased quality of life and significant economic burden. Debridement is a critical component of wound care involving removal of nonviable tissue from chronic wounds to stimulate the granulation and epithelialization process. Clostridial collagenase ointment has been used as a method of wound debridement for more than 50 years and is currently the only enzymatic debriding ointment with US FDA approval. This review discusses the results of recent real-world studies that build upon the evidence demonstrating the clinical effectiveness, cost-effectiveness and safety of clostridial collagenase ointment across wound types and care settings.
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